Detection of colorectal neoplasia with peanut‐agglutinin(PNA)‐reactive carbohydrate structures in rectal mucus

Colonoscopy in colorectal-cancer screening for detection of advanced neoplasia.

BACKGROUND Recommendations for colorectal-cancer screening are based solely on age and family history of cancer, not sex. METHODS We performed a cross-sectional analysis of the data from a large colonoscopy-based screening program that included 50,148 participants who were 40 to 66 years of age. People 40 to 49 years of age were eligible only if they had a family history of cancer of any type...

Local management of rectal neoplasia.

The treatment of rectal neoplasia, whether benign or malignant, challenges the surgeon. The challenge in treating rectal cancer is selecting the proper approach for the appropriate patient. In a small number of rectal cancer patients local excision may be the best approach. In an attempt to achieve two goals-cure of disease with a low rate of local failure and maintenance of function and qualit...

Computer Aided Detection of Potential Colorectal Neoplasia at CT Colonography

Early Detection of and Screening for Colorectal Neoplasia

There are approximately one million new cases of colorectal cancer (CRC) per year worldwide, with substantial associated morbidity and mortality. The long natural history of colorectal neoplasia affords the opportunity to use preventive measures to improve survival in this disease. Currently screening for adenomatous polyps and early-stage cancers is the best methodology for improving survival....

Evaluation of a test for abnormal rectal mucus for early detection of colon cancer.

This report describes the evaluation of a chemical test for T-antigen in rectal mucus as a screening test for colon cancer. The test, called the Mucus Strip Test, detects the disaccharide residue sialic acid-free beta-D-Gal(1-->3)-D-GalNAc or T-antigen, which accumulates in mucus from malignant cells and colonic mucosa adjacent to cancer but not in normal mucosa. Participants were an unselected...